Acetol monooxygenase from Mycobacterium Py1 cleaves acetol into acetate and formaldehyde
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منابع مشابه
Production of acetol from glycerol using engineered Escherichia coli.
Escherichia coli Lin43 is a strain which has some mutations in glycerol kinase (GlpK) and the repressor for the glycerol 3-phosphate regulon (GlpR). When exposed to glycerol, it quickly accumulates lethal levels of methylglyoxal, which is a precursor of acetol; acetol is important for the manufacture of polyols, acrolein, dyes, and skin tanning agents. This work reports the engineering of E. co...
متن کاملRisk evaluation of impurities in topical excipients: The acetol case
Pharmaceutical excipients for topical use may contain impurities, which are often neglected from a toxicity qualification viewpoint. The possible impurities in the most frequently used topical excipients were evaluated in-silico for their toxicity hazard. Acetol, an impurity likely present in different topical pharmaceutical excipients such as propylene glycol and glycerol, was withheld for the...
متن کاملIdentification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes.
Treatment of rabbits with 1% (v/v) acetone for 1 week resulted in the appearance in blood serum of 88 +/- 14 14 nmol/ml 1-hydroxyacetone (acetol) and 70 +/- 9 nmol/ml 1,2-propanediol. Untreated rabbits had no detectable 1,2-propanediol or acetol. Hepatic microsomes from control, ethanol-, and acetone-treated rabbits catalyzed the hydroxylation of acetone at rates of 0.32 +/- 0.01, 2.01 +/- 0.43...
متن کاملThe enzymatic oxidation of 1,2-propanediol phosphate to acetol phosphate.
Lindberg (I) has presented evidence for the occurrence of 1,2propanediol phosphate in beef brain. This compound has also been reported to occur in other tissues (2-4). However, the structure, metabolism, and biological significance of this compound is unknown. Groth et al. (5) have reported that (Y-labeled pyruvate is incorporated into propanediol-P’ under anaerobic conditions in fluoride-inhib...
متن کاملThe metabolism of acetone in rat.
Intraperitoneal injection of 5 mumol of acetone/g, body weight, into 3 rats previously fed 1% acetone (v/v) in their drinking water resulted in the appearance in blood serum of 16 +/- 2 nmol of 1,2-propanediol/ml and 8 +/- 1 nmol of 2,3-butanediol/ml. No detectable 1,2-propanediol or 2,3-butanediol was found in the serum of animals after acetone or saline injection without prior addition of ace...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1986
ISSN: 0378-1097
DOI: 10.1016/0378-1097(86)90303-4